Son of William Farmer Clarke and Gertrude Randall, Byron Hudson Clarke was born on January 25, 1909, in Franklin County, Georgia.

Byron Hudson Clarke married Alice Frances Farr (b. October 14, 1918 – d. March 4, 2004).

As a child, Byron had the mumps - and developed a complication called “Orchitis”. This complication led to sterility. Consequently, Byron and Alice never had any children.

According to Byron nephew, Walter Clarke Randall, Byron had witnessed several terrible atrocities in the Pacific theater of WWII committed by the Japanese. One example, seen in the Manila Massacre, was the common practice of the Japanese soldiers driving bamboo stakes into the ground through women's vaginas. Byron described having seen an entire acre of women staked to the ground in this manner. Consequently, this led Byron to hold a deep resentment toward the Japanese people.

Byron Hudson Clarke died on December 31, 1990… at age 81… after suffering a stroke.