Son of Samuel Sewell, Sr. (1714-1789) and Chrisitan Stover (1716-1775), Samuel Sewell, Jr. was born in 1750.

Samuel Sewell, Jr. married Christian White (1759 - ?).

Samuel Sewell, Jr. and Christian White are believed to have had the following children:

1. Samuel Sewell III (1750-1815) - married Caroline Martha Aderhold
2. John Sewell - Married Elizabeth Christian
3. Mary Sewell - Married James Baker
4. Nickolas Sewell - Married Patsy Christian
5. Rachel Sewell - Married Jacob Burton
6. James Sewell (1783-1859) - Married Polly Baker
7. Issac Sewell (1801-1884) - Married Louisa Lowe (1803-1881)