Son of Samuel Sewell, Sr. (1714-1789) and Chrisitan Stover (1716-1775), Samuel Sewell, Jr. was born in 1750.

Samuel Sewell, Jr. married Christian White (1759 - ?).

Samuel Sewell, Jr. and Christian White are believed to have had the following children:

1. James Sewell (1783-1859) - Married Polly Baker
2. Samuel Sewell III (1786-1852) - married Susannah Chandler (1789 - after 1870)
3. John Sewell - Married Elizabeth Christian
4. Mary Sewell - Married James Baker
5. Nickolas Sewell - Married Patsy Christian
6. Rachel Sewell - Married Jacob Burton
7. Issac Sewell (1801-1884) - Married Louisa Lowe (1803-1881)